Genetic modification of Bluetongue virus by uptake of "synthetic" genome segments
نویسندگان
چکیده
منابع مشابه
Multiple Genome Segments Determine Virulence of Bluetongue Virus Serotype 8
UNLABELLED Bluetongue virus (BTV) causes bluetongue, a major hemorrhagic disease of ruminants. In order to investigate the molecular determinants of BTV virulence, we used a BTV8 strain minimally passaged in tissue culture (termed BTV8L in this study) and a derivative strain passaged extensively in tissue culture (BTV8H) in in vitro and in vivo studies. BTV8L was pathogenic in both IFNAR(-/-) m...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2010
ISSN: 1743-422X
DOI: 10.1186/1743-422x-7-261